by Debra MacKenzie, Ester Erdei, Jennifer Ong, Curtis Miller, and Johnnye Lewis

Introduction: 

From 1948 to 1986, hundred of uranium mining and milling operations were conducted on the Navajo Nation lands. More than 1,000 un-remediated and abandoned mines and associated waste sites remain, leaving a legacy of potential mining waste exposure through drinking water and soil contamination, and from living in homes built with materials containing mining waste. The adverse health outcomes that can be directly attributed to chronic environmental exposure to legacy mine waste are not well established.

Hypothesis:

Our overall hypothesis is t hat environmental exposure to mixed metal legacy mine waste within the Navajo leads to alterations in immune responses or immune dysregulation resulting in increases in TH17 activity and autoimmunity.  

Please click here to see full poster presentation:  MacKenzie_etal_Immune_response_U_exposure_poster_Oct2014

UNM College of Pharmacy, Department of Pharmaceutical Sciences Community Environmental Health Program, Albuquerque, NM.